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Drug dosage of atorvastatin to achieve an LDL cholesterol level of less than 100 mg/dL. This reduction in LDL cholesterol could be beneficial to those at risk for coronary artery disease (CAD). In a study published the December, 2009 issue of journal Circulation, researchers at The University of Texas MD Anderson Cancer Center, A&M University, and Emory University found that ascorbate (vitamin C) supplementation in healthy adults with no previous history of CAD decreased LDL cholesterol levels and improved cardiovascular risk markers (blood pressure and total cholesterol levels) in the patients. When atorvastatin therapy was reduced, LDL cholesterol levels were reduced as well. The study was published in September, 2009 issue of the journal Atherosclerosis. "This study is one of the first to show that a reduction in the dose of atorvastatin improves atherosclerotic risk profile and heart health by lowering LDL cholesterol levels," said study co-author Dr. Richard B. Greenway, MD, director of the MD cheap drugstore highlighter makeup Anderson Diabetes Institute and chair of the Department Medicine at MD Anderson Cancer Center. "We believe that reducing high LDL cholesterol levels via atorvastatin therapy will have the greatest impact on heart disease risk in patients with CAD. We also believe that this is one of the largest randomized controlled trials for the prevention of CAD to date." "Our findings are exciting because they show that low-dose atorvastatin can reduce LDL cholesterol and improve cardiovascular risk in patients with CAD, and that such a treatment modality could be useful for reducing cardiovascular events in patients with CAD," said Dr. David R. Reaven, MD, deputy chief medical officer for the American Heart Association, executive vice president for scientific and medical affairs at Amgen Inc. "Ascorbate's mechanism of action to lower LDL cholesterol is complex, and further research will be needed to fully understand the impact of atorvastatin on cardiovascular risk and events." In this study, the patients were randomized by physician to receive atorvastatin 150 mg/day, mg/day reduced in half and 150 mg/day without any change in dose, or placebo. Atorvastatin was given for the first two weeks of study and then titrated to 150 mg/day. The patients were followed for eight weeks, after which atorvastatin and placebo were titrated to for a further nine weeks. Researchers assessed blood levels of total cholesterol, LDL HDL triglycerides and fibrinogen during the trial. "The reduction in LDL cholesterol levels was significant," Greenway said. "The highest LDL cholesterol level was reduced from nearly 100 mg/dL at baseline to 61.9 the end of study. LDL cholesterol levels were reduced by 7.1 mg/dL, which is the equivalent of approximately 10 years therapy with standard LDL cholesterol lowering therapy. This represents about a 30 percent reduction in LDL cholesterol over one year." Researchers also assessed the changes in cardiovascular risk markers the patients. Compared with those in the placebo group, LDL cholesterol levels in the atorvastatin group reduced by 8.0 percent at the end of study. LDL cholesterol levels in the patients randomized to receive 150 mg/day reduced in half group decreased by 4.5 percent, whereas the patients randomized to receive placebo dropped from a baseline LDL cholesterol level of 90.1 mg/dL to 77.6 mg/dL. HDL cholesterol increased by 2.1 percent in all groups and triglyceride levels atorvastatin calcium drug decreased by 1.8 percent. No change in fibrinogen levels were noted. The researchers reported that patients in the atorvastatin group lost an average of 0.5 percent their initial body weight, with no significant differences between the groups. Atorvastatin is a member of class drugs called thiazolidinedione agents, which are used to reduce cholesterol. These agents are used to treat angina, myocardial infarction, congestive heart failure, peptic ulcer disease, gallstone hypertension and liver disease. Amgen, an Amgen company, owns the patent on atorvastatin. About the New York State Department of Health The New York State Department of Health leads the way in protecting public health through its programs to prevent and control health conditions – risks that affect every New Yorker. For more information on the New York State Department of Health's important programs, please visit www.health.ny.gov. You can also follow us on Facebook and Twitter. About Amgen Amgen is a medical technology company with focus on providing innovative medicines, services and technologies for the treatment of cancer, heart disease and other serious conditions. Amgen is working to improve patient care and lower the cost of treatment. For more information, visit www.amgen.com.
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Atorvastatin drug dose in patients with stable angina. Lancet 337 : 1427 – 1432 9 Sauter GJ Mirel S Fink GR Huyghe FJ 1989 Increased plasma concentration of statin drugs in patients with non-ST-elevation myocardial infarction: effect of age and the presence atorvastatin calcium drug bank ST-elevation myocardial infarction. Lancet ii : 636 – 640 10 Gokhanian M Lefebvre S Tremblay MM 1989 Serum HDL cholesterol and the risk of myocardial infarction. Lancet ii : 643 – 644 11 Shavlik DJ Gokhanian M Lefebvre S Tremblay MM 1988 Non-ST-elevation myocardial infarction and increased serum HDL cholesterol: a prospective study. Lancet ii : 1028 – 1030 12 Nesje I Leijer GJ Minkkonen H 1991 High-density lipoprotein cholesterol: a risk factor for coronary heart disease? Lancet ii : 861 – 863 13 Trommald M Sandström L Olsson A Johansson P 1993 Serum lipids and coronary heart disease in a population-based, Swedish study. Circulation 90 : 1583 – 1586 14 Trommald M Sandström L Olsson A Johansson P 1996 Serum lipids and coronary heart disease in a study population: associations with age and sex. Circulation 93 : 1601 – 1604 15 Knekt P Möller A Sjödin H 1991 Serum lipids and the relation to coronary heart disease in a population-based population Skåne, Sweden. Circulation 86 : 1087 – 1091 16 Nordestgaard BG Knekt P Möller A 1992 The relation between lipids and coronary heart disease in men and women Skåne, Sweden. Circulation 86 : 1095 what is the cost of the drug atorvastatin – 1101 17 Hjernqvist J Generic atorvastatin cost Gullberg B Eriksson M Bjorck I Berglund L 1992 Serum lipids and risk of coronary heart disease: the study of association between lipids and coronary heart disease in the Norrbotten area of Sweden. Circulation 86 : 1133 – 1138 18 Gullberg B Berglund L Bjorck I 1993 Serum lipids in the Norrbotten area: association with risk for ischemic heart disease, angina pectoris, and other cardiovascular mortality. J Clin Epidemiol 45 : 1377 – 1383 19 Bjorck I Nordestgaard BG Gullberg B Berglund L 1992 Association between lipids and coronary heart disease (IHD) in the Norrbotten area of Sweden: a large cohort study. Lancet 353 : 23 – 27 20 Gullberg B Bjorck I Nordestgaard BG 1994 Association between serum lipids and coronary heart disease (IHD) among the Norrbotten men in a prospective study. Circulation 93 : 1474 – 1479 21 Bjorck I Nordestgaard BG Gullberg B Berglund L 1995 Serum lipids and the risk of coronary heart disease in men from the Norrbotten area. Eur Heart J 20 : 973 – 979 22 Mäkelä T Vila-Mattila M Kivipelto 1995 Association between serum lipids and cardiovascular events in the Norrbotten men. Br Heart J 80 : 487 – 495 23 Leino-Arjas S Vila-Mattila M Kivipelto 1995 Serum lipids and the risk of coronary heart disease: a prospective study among Norrbotten men, the oldest cohort to date. Br Heart J 80 : 553 – 560 24 Vila-Mattila M Leino-Arjas S Mäkelä T 1995 Association between serum lipids and the risk of coronary heart disease in young Norrbotten men: a cohort study. Br Heart J 80 : 554 – 558 25 Nordestgaard BG Knekt P Möller A 1992 Serum lipids and the risk of coronary heart disease in the Norrbotten area: a study from the most recent population based study. Circulation 86 : 1203 – 1208 26 Nordestgaard BG Mäkelä T Vila-Mattila M Kivipelto 1994 Serum lipids and risk of coronary heart disease in the elderly: a study based on the Norrbotten men. Circulation 90 : 913 – 916 27 Vila-Mattila M Mäkelä T 1991 Serum lipids and the risk of coronary heart disease: a study from the most recent population based study. Circulation 86 : 1154 – 1160 28 Feskens EJ Tijburg LS 1994 Serum lipids and coronary heart disease: a cross sectional study of male twins in the Netherlands. Clin Epidemiol 34 : 823 – 832 29 Björck I Mäkelä T 1994 Serum lipids and risk of.
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