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Where to buy phenergan in uk This is an open-access article distributed under the terms of Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The purpose of study was to assess the effects of oral treatment with dandelion extract on depression symptoms and anxiety. The aim of study was to investigate whether dandelion extract (DEX) could improve the symptoms of depression in patients with social phobia. The study also aimed to investigate the safety and tolerability of a single dose the extract in healthy participants. Introduction Depression is the fifth leading cause of disability worldwide [1]. Many studies indicate a connection between depression and social phobia (SP), which is characterized by fears of social situations. The World Health Organization (WHO) estimates that about 7 million people worldwide are currently living with a diagnosis of SP. The most common symptoms of SP are fear and avoidance of social situations, feelings hopelessness and worthlessness [2,3]. These symptoms are manifested through the avoidance of social situations and activities through the withdrawal from friends and family. The current evidence supports hypothesis that the beneficial effects of herb, dandelion (Taraxacum officinale), on depression symptoms may be due to the beneficial effects on brain-derived neurotrophic factor (BDNF). BDNF is a neurotrophin expressed in neuronal cells. The main function of BDNF is to promote survival of neurons and to regulate neuronal plasticity, which is essential for the maintenance of mood [4]. BDNF plays a critical role in the regulation of mood, emotions and behavior [5]. In the brain, BDNF is produced in two major neural progenitor cell populations: glial cells and neurogenesis [6]. The majority of BDNF is produced in the dentate gyrus of hippocampus, which is an anterior-lateral region of the hippocampal formation. BDNF is also produced in the olfactory bulb and central nervous system (CNS) neurons in the cortex and subcortical regions [6]. BDNF expression in the dentate gyrus is influenced by the expression of BDNF ligands, such as the neurotrophin receptor TrkB [7]. In addition, BDNF production the nucleus accumbens (NAc) is regulated by the dopamine transporter DAT [8], which facilitates the transfer of BDNF from neurons to the cerebrospinal fluid (CSF) [9]. BDNF is often involved in the regulation of neuronal plasticity and synaptic plasticity. BDNF is also involved in learning and memory [10], as well in neurogenesis [8]. In humans, dandelion (Taraxacum officinale) is a perennial herb having an effective anti-inflammatory effect. It is used for the treatment of cough, inflammation and the inflammatory diseases of nervous system [11]. Although the scientific studies investigating antidepressant effects of dandelion have been reviewed elsewhere, [9]. For the treatment of depression, it is recommended that antidepressants should only be used under the advice and supervision of a healthcare provider. Recent findings on the beneficial effects of dandelion extracts on depression and anxiety have been reported. The extract in form of a tea was found to reduce depression symptoms in participants with social phobia who had not received treatment previously [12]. This study suggested that online pharmacy adderall generic the beneficial effects of dandelion extract can be attributed to its antioxidant activity [13,14]. In a study involving healthy volunteers, dandelion extract was investigated for its effect on the symptoms of depression [15]. According to the findings of this study, dandelion extract reduced depression symptoms by 61.7% (p<0.001). The authors of this study concluded that the extracts of dandelion could effectively treat patients afflicted with depression [15]. The objective of this study was to investigate the safety and tolerability of a single dose the extract of dandelion (DEX) in healthy participants. Materials and methods Study design This double-blind, placebo-controlled, randomized study was performed at the Department of Internal Medicine at The University of Edinburgh, Scotland (see Fig. 1 for participant demographics). The study was approved by university's Research Ethics Committee, and written informed consent was obtained from all participants before the study began. The study was conducted in a double-blind, crossover manner. The first group received placebo extract of dandelion as a single oral dose. The second group received same dose of dandelion extract plus a low dose of d-fenfluramine for four days. To maximize the efficacy of test substance, lowest dose d-fenfluramine.

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